反应详情

温度

20 °C

20 g (0.27 mol) of n-butylamine are dissolved in 100 ml of acetonitrile, and 7.8 g (0.04 mol) of 2-methylpropyl bromoacetate are added at 20° C. The mixture is stirred for 2 hours at 20° C. and subjected to rotary evaporation, the residue is taken up in methylene chloride/water, the organic phase is dried and subjected to rotary evaporation, and the residue is filtered over silica gel (eluent hexane:acetone=7:3). 5.3 g (71% of theory) of 2-methyl-propyl N-butylaminoacetate are obtained.

1. customsubjected to rotary evaporation
2. customthe organic phase is dried
3. customsubjected to rotary evaporation
4. filtrationthe residue is filtered over silica gel (eluent hexane:acetone=7:3)