HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 14839577, compound → 1-(3,8-Diazabicyclo[3.2.1]oct-8-yl)-2,2,2-trifluoroethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 14839577 | HCID 14839577 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(3,8-Diazabicyclo[3.2.1]oct-8-yl)-2,2,2-trifluoroethanone | HCID 14839578 | — |
Reaction Steps
A solution of the 3-benzyl-8-trifluoroacetyl-3,8-diazabicyclo-(3.2.1)octane hydrochloride in 50 mL of methanol was hydrogenated at atmospheric pressure in the presence of 10% Pd/C (0.5 g) until the theoretical quantity of hydrogen was absorbed. The mixture was filtered and the filtrate was evaporated to dryness to yield 1.08 g of titled compound as a white solid. MP 224° C. (dec).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04965273 |
| Source dataset | uspto-grants-1990_10 |
| ORD ID | ord-89231cc68ebc48d1ada94df73f16fb15 |
| Source note | uspto-grants-1990_10 |