HCID 14839583, compound → HCID 14839584, compound

HRID 1089215Notes

Reaction equation

HRID 1089215 reaction equation
Cl.Cl.[F:3][C:4]([F:30])([F:29])[C:5]([NH:7][CH2:8][CH:9]1[CH2:14][N:13](CC2C=CC=CC=2)[CH2:12][CH2:11][N:10]1CC1C=CC=CC=1)=[O:6]>CO.[Pd].O>[F:29][C:4]([F:3])([F:30])[C:5]([NH:7][CH2:8][CH:9]1[CH2:14][NH:13][CH2:12][CH2:11][NH:10]1)=[O:6]

Participants

5

Reactant 1

HCID 14839583HCID 14839583, compound

Product 1

HCID 14839584HCID 14839584, compoundYield 96.8%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a solution of 3.1 g (6.7 mmol) of 2-trifluoroacetylaminomethyl-1,4-diphenylmethyl piperazine dihydrochloride in 100 ml methanol was added a suspension of 0.5 g palladium on carbon in 2 ml water. The mixture was hydrogenized for 30 mn, the catalyst was filtered off and the solvent was removed, taken up in 10 ml absolute ethanol, evaporated again and crystallized in ether to yield 1.37 g of a white powder (72%) as title compound.

Workup

  1. filtrationthe catalyst was filtered off
  2. customthe solvent was removed
  3. customevaporated again
  4. customcrystallized in ether

Sources & evidence

ORD record
ord-af86a5f9ef874019803caff3ff8bd538
Source dataset
uspto-grants-1990_10
Patent number
US04965273

Reaction notes

Loading…