HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(Aminomethyl)pyrrolidin-3-ol dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-Hydroxy-4-aminomethyl-1-phenylmethyl pyrrolidine | HCID 13959893 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(Aminomethyl)pyrrolidin-3-ol dihydrochloride | HCID 14839587 | 70% |
Reaction Steps
A solution of 2.9 g (10.6 mmol) of 3-hydroxy-4-aminomethyl-1-phenylmethyl pyrrolidine in 60 ml anhydrous methanol and 5.3 ml 5N hydrochloric acid in ethanol was hydrogenized over 1.83 g palladium on carbon for 17 hours. The catalyst was filtered off, the solvent removed to afford 1.39 g (70%) of title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04965273 |
| Source dataset | uspto-grants-1990_10 |
| ORD ID | ord-b559d7a33a894657babbbff36d1cdec3 |
| Source note | uspto-grants-1990_10 |