反应详情

A suspension of 76 g (0.217 moles) of (1R, 4R)-5-phenylmethyl-2,5-diazabicyclo-[2.2.1]-heptane, dihydrobromide (9) and 37 g of 10% Pd on C in 1.2 L of water was hydrogenated at atmospheric pressure at 40° C. The reaction was completed within 8 hours. The catalyst was filtered off and the filtrate was evaporated under reduced pressure. The residue was taken up with ethanol and the resulting precipitate was filtered to give 51.4 g (91%) of the titled compound. M.P.=285°. [α]D =-19.83 (c=1.2, 0.1N HCL).

1. customwas hydrogenated at atmospheric pressure at 40° C
2. filtrationThe catalyst was filtered off
3. customthe filtrate was evaporated under reduced pressure
4. filtrationthe resulting precipitate was filtered