HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1089246Generated: November 1, 2026
Formic Acid → N-(4,6-dichloro-2-formamido-pyrimidin-5-yl)formamide
https://huagongshe.com/reaction/1089246
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 2,5-Diamino-4,6-dichloropyrimidine | HCID 301039 | — |
| Product | N-(4,6-dichloro-2-formamido-pyrimidin-5-yl)formamide | HCID 13989892 | 60% |
Reaction Steps
Acetic anhydride (40 ml) was added dropwise over 10 minutes to a mixture of 2,5-diamino-4,6-dichloropyrimidine (8.0 g, 44.7 mmol) and formic acid (100 ml) at 0° C. The mixture was stirred at 20° C. for 4 hours, evaporated to dryness and co-evaporated with toluene. Solidification from acetone-hexane afforded the title compound (6.1 g, 60%). IR: υmax (KBr) 3230, 1715, 1680, 1575, 1550, 1485, 1415 cm-1. Found m/e 233.9695; C6H4N4O2Cl2 requires 233.9709.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04965270 |
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| Source dataset | uspto-grants-1990_10 |
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| ORD ID | ord-e462c844d81c4a4bad308da2a54bbdab |
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| Source note | uspto-grants-1990_10 |
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