Diglyme → HCID 22160583, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2,4-dichloro-5-formamidopyrimidine (2.5 g, 13.0 mmol), 2,2-dimethyl-1,3-dioxan-5-yl-methoxyamine (13.6 mmol), diisopropylethylamine (4.5 ml, 25.8 mmol) and 2-methoxyethyl ether (50 ml) was heated at 100° C. for 4.5 hours. The suspension was cooled and evaporated under reduced pressure. The residue was chromatographed on silica gel (eluted with chloroform-methanol, 20:1), yielding the title compound (3.45 g, 84%).

Provenance & Evidence