HCID 22160583, compound → HCID 22160556, compound

HRID 1089282Notes

Reaction equation

[Cl:1][C:2]1[N:7]=[C:6]([NH:8][O:9][CH2:10][CH:11]2[CH2:16][O:15][C:14]([CH3:18])([CH3:17])[O:13][CH2:12]2)[C:5]([NH:19][CH:20]=O)=[CH:4][N:3]=1>C(OC(OC(=O)C)OCC)C>[Cl:1][C:2]1[N:7]=[C:6]2[C:5]([N:19]=[CH:20][N:8]2[O:9][CH2:10][CH:11]2[CH2:16][O:15][C:14]([CH3:18])([CH3:17])[O:13][CH2:12]2)=[CH:4][N:3]=1

Participants

Conditions

Temperature: 20 °C

Procedure

2-Chloro-4-(2,2-dimethyl-1,3-dioxan-5-ylmethoxyamino)-5-formamidopyrimidine (3.45 g, 10.9 mmol) in diethoxymethylacetate (100 ml) was heated at 120° C. for 2 hours. The mixture was then cooled and evaporated to a syrup. The residue was dissolved in methanol (50 ml) and concentrated aqueous ammonia (2.5 ml). The solution was then stirred at 20° C. for 1 hour, evaporated under reduced pressure and the residue co-evaporated with toluene. Column chromatography on silica gel (eluted with chloroform-methanol, 60:1) gave the title compound (2.27 g, 70%). IR: υmax (KBr) 3117, 2993, 1599, 1571, 1339 cm-1. 1H NMR: δH [(CD3)2SO] 1.33 (3H,s,CH3), 1.37 (3H,s,CH3), 2.08 (1H,m,CH), 3.81 (2H,d.d, J=5.8, 2.1 Hz, 2×H(ax)). 4.04 (2H, d.d, J=4.0, 12.0 Hz. 2×H (eq)), 4.52 (2H, d, J=3.3 Hz, CH2ON), 9.00 (1H,s,H-8), 9.14(1H,s,H-6). Found: C, 48.34; H, 5.13; N, 18.66%: C12H15ClN4O3 requires: C, 48.24; H, 5.07; N, 18.76%.

Workup

temperatureThe mixture was then cooled
customevaporated to a syrup
dissolutionThe residue was dissolved in methanol (50 ml)
customevaporated under reduced pressure

Sources & evidence

ORD record: ord-1298c3795deb4e4299a1993b4a0e5e32
Source dataset: uspto-grants-1990_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04965270

Reaction notes

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