Sodium Hydroxide → 1,5-Bis(4'-carboxyphenyl)-3-pentanol

Participants

Reaction Steps

A mixture of 1,5-bis(4'-methoxycarbonylphenyl)-3-pentanol and 1 L of 3 M aqueous sodium hydroxide are heated at reflux for 7 hours, the resulting reaction mixture is allowed to cool to room temperature and added to a stirred mixture of 300 mL concentrated hydrochloric acid and 200 g of ice. The precipitate is collected by filtration and recrystallized from 3 L of acetic acid. The purified product is dried by heating under vacuum to give 330 g (100% of theory) of 1,5-bis(4'-carboxyphenyl)-3-pentanol as a white, fine, crystalline powder.

Provenance & Evidence