Methanol → 1-(3,5-Dichlorophenyl)-4-methoxycarbonyl-5-pyrazolecarboxamide

Participants

Reaction Steps

A 1.5 g portion of the compound of Example 2 was suspended in 30 ml of methanol, and hydrogen chloride gas was bubbled through the suspension for 1 minute. Then 30 ml of methanol was added over a 5 minute period while the addition of gas was continued. Then the mixture was heated under reflux for 2 hours, and was cooled and filtered. The solids were collected and dried to obtain 1.15 g of the desired product, m.p. 220°-222°.

Provenance & Evidence