Sodium ion → 3-bromo-5-(2,6-difluorophenyl)-7-(1H-pyrazol-4-yl)-2-{[2-(trimethylsilyl)ethoxy]methyl}-2H-pyrazolo[4,3-c]isoquinoline
Reaction equation
[Br:1][c:2]1[n:3]([CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:29])([CH3:30])[CH3:31])[n:4][c:5]2[c:6]1[n:7][c:8](-[c:16]1[c:17]([F:23])[cH:18][cH:19][cH:20][c:21]1[F:22])[c:9]1[cH:10][c:11]([I:15])[cH:12][cH:13][c:14]21.[CH2:32]1[O:33][CH2:34][CH2:35][O:36][CH2:37]1.[Na+:46].[Na+:47].[O-:48][C:49](=[O:50])[O-:51].[OH2:129].[cH:52]1[cH:53][cH:54][c:55]([P:56]([Pd:57]([P:58]([c:59]2[cH:60][cH:61][cH:62][cH:63][cH:64]2)([c:65]2[cH:66][cH:67][cH:68][cH:69][cH:70]2)[c:71]2[cH:72][cH:73][cH:74][cH:75][cH:76]2)([P:77]([c:78]2[cH:79][cH:80][cH:81][cH:82][cH:83]2)([c:84]2[cH:85][cH:86][cH:87][cH:88][cH:89]2)[c:90]2[cH:91][cH:92][cH:93][cH:94][cH:95]2)[P:96]([c:97]2[cH:98][cH:99][cH:100][cH:101][cH:102]2)([c:103]2[cH:104][cH:105][cH:106][cH:107][cH:108]2)[c:109]2[cH:110][cH:111][cH:112][cH:113][cH:114]2)([c:115]2[cH:116][cH:117][cH:118][cH:119][cH:120]2)[c:121]2[cH:122][cH:123][cH:124][cH:125][cH:126]2)[cH:127][cH:128]1.[nH:38]1[n:39][cH:40][c:41]([B:43]([OH:44])[OH:45])[cH:42]1>>[Br:1][c:2]1[n:3]([CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:29])([CH3:30])[CH3:31])[n:4][c:5]2[c:6]1[n:7][c:8](-[c:16]1[c:17]([F:23])[cH:18][cH:19][cH:20][c:21]1[F:22])[c:9]1[cH:10][c:11](-[c:41]3[cH:40][nH:39][n:38][cH:42]3)[cH:12][cH:13][c:14]21Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-152f2b874a09421c8f92b3bb49e6bea4
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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