3-Furoic acid → HCID 54021445, compound

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Reaction Steps

3-Furoic acid (0.355 g) and 2,4,6-triisopropyl benzene-sulfonyl chloride (0.96 g) were dissolved in dry pyridine (5 ml). The mixture was stirred for 1 hour. To the mixture were added 2',3'-bis-O-(tert-butyldimethylsilyl)-5'-deoxy-5-fluorocytidine (1.0 g) obtained in Reference example (a) and 4-dimethylaminopyridine (0.80 g). After stirring of the mixture for 12 hours at room temperature. pyridine was evaporated under reduced pressure. The residue was then treated as in Example 48 to give 0.55 g of 5'-deoxy-5-fluoro-N4 -(3-furoyl)cytidine, mp 173°~174° C. (ethanol); MS 340 (MH+).

Provenance & Evidence