Chloroacetone → HCID 14536733, compound

Participants

Reaction Steps

71.5 g (0.70 mol) of (2-acetylaminoethyl)-amine are slowly added to 40.7 g (0.35 mol) of methyl acetoacetate. 32.4 g (0.35 mol) of chloroacetone are then added dropwise and the mixture is heated under reflux for 20 hours. After cooling, water is added, the mixture is extracted with methylene chloride and the extract is concentrated. The residue is recrystallized from ethyl acetate (filtered over active charcoal and silica gel).

Provenance & Evidence