HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 1-(2-Acetylaminoethyl)-2,5-dimethylpyrrole-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | N-(2-(3-Formyl-2,5-dimethyl-1H-pyrrol-1-yl)ethyl)acetamide | HCID 178134 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-(2-Acetylaminoethyl)-2,5-dimethylpyrrole-3-carbonitrile | HCID 14536745 | — |
Reaction Steps
5.2 g (0.025 mol) of 1-(2-acetylaminoethyl)-2,5-dimethylpyrrole-3-aldehyde, 1.75 g (0.025 mol) of hydroxylamine hydrochloride and 2 ml (0.025 mol) of pyridine are heated under reflux in 25 ml of toluene for 1.5 hours. After the mixture has been concentrated, the residue is taken up in water, the mixture is extracted with methylene chloride and the product is recrystallized from toluene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04966901 |
| Source dataset | uspto-grants-1990_10 |
| ORD ID | ord-418c1f690c9444beb44ce2e475a5d1a4 |
| Source note | uspto-grants-1990_10 |