HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 3-Acetyl-1-(2-acetylaminoethyl)-2,5-dimethylpyrrole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 1,2-Dimethoxyethane | HCID 8071 | — |
| Reactant | N-(2-(2,5-Dimethyl-1H-pyrrol-1-yl)ethyl)acetamide | HCID 13770049 | — |
| Catalyst | Zincchloride | HCID 3007855 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 3-Acetyl-1-(2-acetylaminoethyl)-2,5-dimethylpyrrole | HCID 14536752 | — |
Reaction Steps
13.7 g (0.1 mol) of anhydrous zinc chloride are dissolved in 100 ml of ether and the solution is added to 18.0 g (0.1 mol) of 1-(2-acetylaminoethyl)-2,5-dimethylpyrrole and 9.5 ml (0.1 mol) of acetic anhydride in 50 ml of ether. After 1 hour at room temperature, 50 ml of ethylene glycol dimethyl ether are added and stirring is continued for 20 hours. After the hydrolysis, the organic phase is concentrated, the residue is chromatographed and the product is recrystallized from ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04966901 |
| Source dataset | uspto-grants-1990_10 |
| ORD ID | ord-59c3126467824be7ae7abe85ece5af9a |
| Source note | uspto-grants-1990_10 |