Ethanol → HCID 22159354, compound

Participants

Reaction Steps

1.6 g (0.053 mol) of 80% strength sodium hydride in white oil are suspended in 50 ml of dimethyl sulfoxide and 2.5 g (0.055 mol) of ethanol are added dropwise at 15°-20° C. After completion of gas evolution, a solution of 1.0 g (0.005 mol) of 2-(6-chloro-pyridazin-3-yl)-2-methylpropanol in 20 ml of dimethyl sulfoxide is allowed to run in and the mixure is warmed to 90°-100° C. for 1.5 hours. After cooling, the mixture is poured into concentrated sodium chloride solution and extracted with ether. After removing the solvent, a yellow oil remains as the crude product. Yield: 0.6 g (61% of theory).

Provenance & Evidence