Hydrochloric Acid → HCID 15114606, compound

Participants

Reaction Steps

A stirred mixture of 1-(4-chlorobenzoyl)-4-benzylsemicarbazide (16.15 g, 5.317×10-2 mole) and 1 molar aqueous NaOH (64 ml, 6.4×10-2 mole) was heated to reflux. After refluxing ca. 22 hrs., the reaction was allowed to cool slightly before being neutralized by the addition of concentrated aqueous HCl (5.5 ml, 6.6×10-2 mole). A colorless solid formed and after the mixture had cooled to room temperature this was collected by filtration. Crystallization from isopropanol afforded colorless needles: 12.76 g (84%), mp. 208°-210° C.

Provenance & Evidence