Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1089549Generated: October 29, 2026

Formaldehyde → 4-(1H-Imidazol-1-yl)benzeneacetic acid, methyl ester

https://huagongshe.com/reaction/1089549

Reaction equation

Participants

RoleNameHCIDCharge
ReactantFormaldehydeHCID 712—
ReactantGlyoxalHCID 7860—
ReactantAmmonium HydroxideHCID 14923—
ReactantMethyl 2-(4-aminophenyl)acetateHCID 2761030—
Product4-(1H-Imidazol-1-yl)benzeneacetic acid, methyl esterHCID 14856360—

Reaction Steps

In a manner similar to preparation 4, react 4-aminobenzeneacetic acid, methyl ester with ammonium hydroxide, glyoxal, and formaldehyde to obtain the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04966967
Source datasetuspto-grants-1990_10
ORD IDord-134ecd27ed404bc78d125276b350c4f3
Source noteuspto-grants-1990_10