Methanesulfonyl chloride → Methyl 2-[4-(Methylsulfonamido)phenyl]acetate

HRID 1089550Notes

Reaction equation

HRID 1089550 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:4][CH:3]=1.[CH3:13][S:14](Cl)(=[O:16])=[O:15]>N1C=CC=CC=1>[CH3:13][S:14]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:6][CH:7]=1)(=[O:16])=[O:15]

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 2761030Methyl 2-(4-aminophenyl)acetate

Product 1

HCID 14856363Methyl 2-[4-(Methylsulfonamido)phenyl]acetate

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

In a manner similar to preparation 3, react 4-aminobenzeneacetic acid, methyl ester with methanesulfonyl chloride, and pyridine to obtain the title compound.

Workup

  1. customIn a manner similar to preparation 3

Sources & evidence

ORD record
ord-9e8f09d67a16466dafcc43a39ea723f4
Source dataset
uspto-grants-1990_10
Patent number
US04966967

Reaction notes

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