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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1089551Generated: October 27, 2026

Methyl 2-[4-(Methylsulfonamido)phenyl]acetate → 9-(1H-Imidazol-1-yl)-4-[2-[4-[(methylsulfonyl)amino]phenyl]acetyl]-3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonine

https://huagongshe.com/reaction/1089551

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 2-[4-(Methylsulfonamido)phenyl]acetateHCID 14856363—
Reactant9-(1H-imidazol-1-yl)-3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonineHCID 14856364—
ReactantTrimethylaluminumHCID 16682925—
Product9-(1H-Imidazol-1-yl)-4-[2-[4-[(methylsulfonyl)amino]phenyl]acetyl]-3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonineHCID 14856365—

Reaction Steps

In a manner similar to preparation 7, react 9-(1H-imidazol-1-yl)-3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonine, trimethylaluminum, and 4-[(methylsulfonyl)amino]benzeneacetic acid, methyl ester to obtain the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04966967
Source datasetuspto-grants-1990_10
ORD IDord-4851d7e94ae54af1bcc1fd6f6169ac5e
Source noteuspto-grants-1990_10