9-(1H-Imidazol-1-yl)-4-[2-[4-(1H-imidazol-1-yl)phenyl]acetyl]-3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonine → 9-(1H-Imidazol-1-yl)-4-[2-[4-(1H-imidazol-1-yl)phenyl]ethyl]-3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonine

HRID 1089559Notes

Reaction equation

HRID 1089559 reaction equation
[N:1]1([C:6]2[CH:32]=[CH:31][C:9]3[O:10][CH2:11][CH2:12][N:13]([C:17](=O)[CH2:18][C:19]4[CH:24]=[CH:23][C:22]([N:25]5[CH:29]=[CH:28][N:27]=[CH:26]5)=[CH:21][CH:20]=4)[CH2:14][CH2:15][O:16][C:8]=3[CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[N:1]1([C:6]2[CH:32]=[CH:31][C:9]3[O:10][CH2:11][CH2:12][N:13]([CH2:17][CH2:18][C:19]4[CH:20]=[CH:21][C:22]([N:25]5[CH:29]=[CH:28][N:27]=[CH:26]5)=[CH:23][CH:24]=4)[CH2:14][CH2:15][O:16][C:8]=3[CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 148563669-(1H-Imidazol-1-yl)-4-[2-[4-(1H-imidazol-1-yl)phenyl]acetyl]-3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonineHCID 21226445Aluminium lithium hydride

Product 1

HCID 148563739-(1H-Imidazol-1-yl)-4-[2-[4-(1H-imidazol-1-yl)phenyl]ethyl]-3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonine

Procedure

In a manner similar to example 8, react 9-(1H-imidazol-1-yl)-4-[2-[4-(1H-imidazol-1-yl)phenyl]acetyl]-3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonine with lithium aluminum hydride to obtain the title compound.

Sources & evidence

ORD record
ord-c6f2de87c28a48c0adc056648886d2d5
Source dataset
uspto-grants-1990_10
Patent number
US04966967

Reaction notes

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