反应详情

According to the procedure of W. Adcock, et al. Aust. J. Chem. 18, 1351 (1965), a mixture of ethyl 8-amino-2-naphthoate (5.2 g, 0.024 mol), 1N NaOH (48 mL, 0.048 mol), and dioxane (50 mL) was stirred at room temperature for 3 hours. The dioxane was removed under reduced pressure, and the aqueous phase was diluted with H2O (100 mL) and extracted with ether. Neutralization with acetic acid produced a yellow precipitate which was collected by filtration (3.2 g, 71%), m.p. 221°-223° C.

1. customThe dioxane was removed under reduced pressure
2. additionthe aqueous phase was diluted with H2O (100 mL)
3. extractionextracted with ether
4. customNeutralization with acetic acid produced a yellow precipitate which
5. filtrationwas collected by filtration (3.2 g, 71%), m.p. 221°-223° C.