[1-(4-Methoxyphenyl)-2,2,2-trifluoroethoxy]tris(diethylamino)phosphonium bromide → 1-(1-Bromo-2,2,2-trifluoroethyl)-4-methoxybenzene

Participants

Reaction Steps

In a round-bottom flask equipped with reflux condenser, 53.2 g (0.1 mol) [1-(4-methoxyphenyl)-2,2,2-trifluoroethoxy]tris(diethylamino)phosphonium bromide (product from Example 5) were refluxed in 80 ml of methyl isobutyl ketone for 10 minutes. The subsequent distillation gave 22.2 g (83% of yield) of 1-(1-bromo-2,2,2-trifluoroethyl)-4-methoxybenzene (b.p. 108° to 110° C./8 mbar).

Provenance & Evidence