Hydrochloric Acid → HCID 86744323, compound

Participants

Reaction Steps

To a 0° C. solution of 7 (1.16 g, 4.07 mmol) in dry pyridine (3 mL) was added p-toluenesulfonyl chloride (0.707 g, 2.72 mmol) and the mixture allowed to warm to room temperature and stir for 1 hour. The reaction mixture was poured into ice water (25 mL) and acidified with 2N HCl. The resulting precipitate was collected by filtration, washed with water (2×5 ML), and vacuum dried to give 8a. 2,3-Dihydro-4-(3-hydroxypropyl)-5-benzyloxybenzofuran tosylate (8b) can be produced in similar fashion

Provenance & Evidence