Ethylene Glycol → HCID 19915466, compound

Participants

Reaction Conditions

Reaction Steps

27 g of 4-chloro-5-trifluoromethyl-1,3-dinitrobenzene are initially introduced into 37 g of ethylene glycol, and 11.4 g of 50 percent strength aqueous sodium hydroxide solution are added dropwise at 45° C. in the course of 20 minutes. The mixture is subsequently stirred at 45° C. for 1 hour, a further 1.5 g of sodium hydroxide solution are added, the mixture is subsequently stirred at 45° C. for 1 hour, a furthere 1.5 g of sodium hydroxide solution are added, the mixture is subsequently stirred at 45° C. for a further hour and 200 ml of water are then added. The oil which has separated out is separated off, washed twice with 30 ml of water each time and dissolved in 75 ml of ethyl acetate and the solution is washed again with water. The ethyl acetate phase is then dried and concentrated.

Provenance & Evidence