Tetrahydropyran-2-methanol → HCID 19915453, compound

HRID 1089625Notes

Reaction equation

HRID 1089625 reaction equation
Cl[C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][C:5]([N+:12]([O-])=O)=[CH:4][C:3]=1[N+:15]([O-])=O.[OH:18][CH2:19][CH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][O:21]1.[OH-].[Na+]>O>[O:21]1[CH2:22][CH2:23][CH2:24][CH2:25][CH:20]1[CH2:19][O:18][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][C:5]([NH2:12])=[CH:4][C:3]=1[NH2:15]

Participants

5

Reactant 3

HCID 7524Tetrahydropyran-2-methanolHCID 14798Sodium HydroxideHCID 67851Benzene, 2-chloro-1,5-dinitro-3-(trifluoromethyl)-

Product 1

HCID 19915453HCID 19915453, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

27 g of 4-chloro-5-trifluoromethyl-1,3-dinitrobenzene are initially introduced into 36 g of 2-hydroxymethyltetrahydropyran, and 8.8 g of 50 percent strength aqueous sodium hydroxide solution are added at 45° C. in the course of 30 minutes. The mixture is then subsequently stirred at 45° for one hour and 30 ml of water are added. The oil which has separated out is separated off, washed twice with 20 ml of water each time and dried. This gives 18.3 g (53% of the theoretical value) of yellow oil.

Workup

  1. additionare added at 45° C. in the course of 30 minutes
  2. customThe oil which has separated out
  3. customis separated off
  4. washwashed twice with 20 ml of water each time
  5. customdried

Sources & evidence

ORD record
ord-46445325775d46c9b314948315f8642e
Source dataset
uspto-grants-1992_01
Patent number
US05078748

Reaction notes

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