Potassium Iodide → HCID 19915644, compound

Participants

Reaction Steps

(+)-5-(7-benzofuranyl)-8-chloro-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-ol (1.64 g, 0.005 mol) is suspended in dry ethanol (50 ml). Potassium-tert.-butylate (1.12 g, 0.010 mol) and potassiumiodide (0.10 g) are added. To the resulting solution chloromethyl methyl ether (0.84 g, 0.010 mol) is added. The reaction mixture is stirred for 3 hours. The resulting suspension is filtered and the filtrate evaporated to dryness under reduced pressure. The residue is chromatographed on a silicia-gel column, using dichloromethane/methanol (25:1) as the eluent. The fractions containing the product are collected and evaporated to dryness under reduced pressure.

Provenance & Evidence