Chloromethyl Methyl Ether → HCID 67903711, compound

Participants

Reaction Conditions

Reaction Steps

(+)-8-chloro-5-(2,3-dihydrobenzofuran-7-yl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-ol (4.95 g, 0.015 mol) and potassium-tert butylate (1.85 g, 0.016 mol) are dissolved in dry tetrahydrofuran (40 ml) at 5° C. Chloromethyl methyl ether (1.51 g, 0.019 mol) is added, the temperature raising to 35° C. The reaction mixture is stirred for three hours, then evaporated to dryness under reduced pressure. The residue is partitioned between water and toluene after adjusting the pH to 8.0 by addition of 1N sodiumhydroxide. The toluene phase is dried over magnesium sulphate, and evaporated to dryness under reduced pressure. The residue is crystallized from ethylacetate (11 ml).

Provenance & Evidence