Chloromethyl Methyl Ether → HCID 67903759, compound

Participants

Reaction Steps

(+)-5-(2,3-dihydrobenzofuran-7-yl)-8-iodo-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-ol (126.0 mg, 3.0 mmol) and potassiumm-tert-butylate 37.0 mg, 3.3 mmol) are dissolved in dry tetrahydrofuran (10 ml) at 20° C. Chloromethyl methyl ether (30.0 mg, 3.8 mmol) is added. The reaction mixture is stirred for 3.5 hours then poured into 5% sodiumhydrogencarbonate (20 ml). The product is extracted into dichloromethane (2×15 ml). The organic phase is evaporated to dryness under reduced pressure.

Provenance & Evidence