Sodium Cyanide → HCID 19915659, compound

HRID 1089678Notes

Reaction equation

HRID 1089678 reaction equation
[NH2:1][N:2]1[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1.[C-:8]#[N:9].[Na+].[CH2:11]([S:18][CH2:19][CH:20]([CH3:23])[CH:21]=O)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[CH2:11]([S:18][CH2:19][CH:20]([CH3:23])[CH:21]([NH:1][N:2]1[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1)[C:8]#[N:9])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 3

HCID 8929Sodium CyanideHCID 20315N-AminomorpholineHCID 14711116HCID 14711116, compound

Product 1

HCID 19915659HCID 19915659, compoundYield 95.7%

Procedure

5.8 g of 4-aminomorpholine, 2.7 g of sodium cyanide and 10.7 g of 3-benzylthio-2-methylpropionaldehyde are reacted analogously to 7a). 16.1 g of 4-benzylthio-2-morpholinoamino-3-methylbutyronitrile are obtained, which are employed in the following step without further purification.

Sources & evidence

ORD record
ord-463f2ba78e45425ca325cfe4b8c0477e
Source dataset
uspto-grants-1992_01
Patent number
US05079244

Reaction notes

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