p-Toluenesulfonic acid monohydrate → HCID 21982236, compound

Participants

Reaction Steps

Ethyl 2-(5-bromo-1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-3-oxo-butyrate was prepared (168 mg, 31%) in the same manner as described in the above example 6 (20) from ethyl 3-(5-bromo-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methyl-[1,3]dioxolan-2-yl)propionate (0.41 g, 1.36 mmol) and p-toluenesulfonic acid monohydrate (50 mg), and the obtained product was identified with the following NMR data.

Provenance & Evidence