HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonyl chloride → Dofetilide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 1-(4-aminophenoxy)-2-[N-methyl-N-(4-methanesulphonamidophenethyl)amino]ethane dihydrochloride hemihydrate | HCID 67895548 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Dofetilide | HCID 71329 | — |
Reaction Steps
The title compound was prepared by mesylation of 1-(4-aminophenoxy)-2-[N-methyl-N-(4-methanesulphonamidophenethyl)amino]ethane dihydrochloride hemihydrate (95 mg) with mesyl chloride in pyridine according to the procedure of Example 19(C), yield 30 mg, m.p. 147°-149°, confirmed spectroscopically to be identical to the product of Example 7(C).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05079248 |
| Source dataset | uspto-grants-1992_01 |
| ORD ID | ord-5b11486c07814e9286709eb1527e37c0 |
| Source note | uspto-grants-1992_01 |