1H-Imidazole-1-propanamine → HCID 10137772, compound

HRID 1089747Notes

Reaction equation

HRID 1089747 reaction equation
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:4]=[C:5]([CH2:9][N:10]2[C:18]3[C:13]4[C:14](=[CH:19][CH:20]=[CH:21][C:12]=4[C:11]2=S)[CH:15]=[CH:16][CH:17]=3)[CH:6]=[CH:7][CH:8]=1.[N:25]1([CH2:30][CH2:31][CH2:32][NH2:33])[CH:29]=[CH:28][N:27]=[CH:26]1>C(O)C>[F:1][C:2]([F:24])([F:23])[C:3]1[CH:4]=[C:5]([CH2:9][N:10]2[C:18]3[C:13]4[C:14](=[CH:19][CH:20]=[CH:21][C:12]=4[C:11]2=[N:33][CH2:32][CH2:31][CH2:30][N:25]2[CH:29]=[CH:28][N:27]=[CH:26]2)[CH:15]=[CH:16][CH:17]=3)[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 787361H-Imidazole-1-propanamineHCID 15023417HCID 15023417, compound

Product 1

HCID 10137772HCID 10137772, compoundYield 66.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2.5 g of 1-[[3-(trifluoromethyl) phenyl]methyl]benz[cd]indole-2(1H)-thione (Ch), 0.95 g of 1H-imidazole-1-propanamine, 200 ml ethyl alcohol and 2.3 g of mercuric acetate is reacted as described in Example 3, giving 2.1 g of the desired product, mp. 108°-109° C.

Workup

  1. customis reacted

Sources & evidence

ORD record
ord-c579c58037404950a69867dfdf41de30
Source dataset
uspto-grants-1992_01
Patent number
US05079247

Reaction notes

Loading…