反应详情

A mixture containing 0.0046 mol of 4-[(4-fluorophenyl)phenylmethylene]piperidine, 0.0055 mol of the compound obtained in Stage A, 0.028 mol of sodium carbonate and 0.1 g of potassium iodide in 100 ml of 4-methyl-2-pentanone is brought to reflux for 8 hours. The mixture is concentrated under vacuum. The residue is taken up in water and the product is extracted with dichloromethane. After evaporation of the solvent, the product is solubilized in a mixture of ethyl ether and acetone and converted to a hydrochloride after the addition of hydrochloric acid. The salt is recrystallized in acetone.

1. temperatureto reflux for 8 hours
2. concentrationThe mixture is concentrated under vacuum
3. extractionthe product is extracted with dichloromethane
4. customAfter evaporation of the solvent
5. additionthe product is solubilized in a mixture of ethyl ether and acetone
6. additionafter the addition of hydrochloric acid
7. customThe salt is recrystallized in acetone