Hexane → Flosequinoxan

HRID 1089783Notes

Reaction equation

HRID 1089783 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:12](=[O:18])[CH2:13][S:14]([CH3:17])(=[O:16])=[O:15])=[C:6]([CH:11]=1)[N:7]([CH3:10])[CH:8]=O.CCCCCC>N1C=CC=CC=1>[F:1][C:2]1[CH:11]=[C:6]2[C:5]([C:12](=[O:18])[C:13]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:8][N:7]2[CH3:10])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 8058HexaneHCID 867447425'-fluoro-N-methyl-2'-methylsulphonylacetylformanilide

Product 1

HCID 131270Flosequinoxan

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 5'-fluoro-N-methyl-2'-methylsulphonylacetylformanilide (0.85 g), prepared in a similar manner to that described in Example 11, in pyridine (85 ml) was stirred at ambient temperature for 3 days. The mixture was added to hexane (180 ml) and the solid collected by filtration was dried at 50° in vacuo to give 7-fluoro-1-methyl-3-methylsulphonyl-4-quinolone, m.p.234°-235° (0.49 g).

Workup

  1. filtrationthe solid collected by filtration
  2. customwas dried at 50° in vacuo

Sources & evidence

ORD record
ord-7f0bb900f86b4d2889e029fb83944fad
Source dataset
uspto-grants-1992_01
Patent number
US05079264

Reaction notes

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