Acetic Anhydride → HCID 53934549, compound

HRID 1089817Notes

Reaction equation

HRID 1089817 reaction equation
[CH2:1]([O:3][C:4]([C:6]1([C:23]([O:25][CH2:26][CH3:27])=[O:24])[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH3:16])[CH:13]=2)[NH:8][CH:7]1[CH:17]=[CH:18][C:19]([O:21][CH3:22])=[O:20])=[O:5])[CH3:2].[C:28](OC(=O)C)(=[O:30])[CH3:29]>>[C:28]([N:8]1[C:9]2[C:14](=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=2)[C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])([C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH:7]1[CH:17]=[CH:18][C:19]([O:21][CH3:22])=[O:20])(=[O:30])[CH3:29]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 53813200HCID 53813200, compound

Product 1

HCID 53934549HCID 53934549, compound

Procedure

The crude indoline 9 was dissolved in acetic anhydride (35 ml). This solution was stirred for 1 h at room temperature. Thereupon the acetic anhydride was removed in vacuo. The residue (~27 g) was sufficiently pure for further conversions. A sample of this residue was purified by flash column chromatography (SiO2, CH2Cl2 /acetone 95/5). A pale yellow oily product was obtained.

Workup

  1. customThereupon the acetic anhydride was removed in vacuo
  2. customA sample of this residue was purified by flash column chromatography (SiO2, CH2Cl2 /acetone 95/5)
  3. customA pale yellow oily product was obtained

Sources & evidence

ORD record
ord-9b471880ba994c72b7f2635159ee6b70
Source dataset
uspto-grants-1992_01
Patent number
US05079257

Reaction notes

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