Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 2-Methylfluorene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Fluorene-2-carboxaldehyde | HCID 34804 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium hydroxide | HCID 9942167 | — |
| 용매 | Hexane | HCID 8058 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 2-Methylfluorene | HCID 15026 | 69.1% |
반응 단계
A solution of 2-fluorenecarboxaldehyde (15 g, 77.1 mmol) in 250 mL of 10% solution of acetic acid in ethyl acetate was hydrogenated at 80 psi of hydrogen during 24 hours at room temperature over 20% palladium hydroxide on carbon (catalytic amount). The reaction was monitored by TLC (silica, 25% ethyl acetate in hexane). The catalyst was filtered off, evaporation of the solvents followed by recrystallization of the residual solid from ethanol:water 5:1 afforded 9.6 g (69.0%) of the product as colorless solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05079260 |
| 출처 데이터셋 | uspto-grants-1992_01 |
| ORD ID | ord-8f6e1c3af9924fbfa04f62eb84f9198e |
| 출처 메모 | uspto-grants-1992_01 |