HCID 131717138, compound → HCID 67719545, compound

Participants

Reaction Steps

4,4-Dimethyldiphenic acid (20.0 g, 74.0 mmol) was heated in a sand bath at 300°-330° C. for 2 hr until decarboxylation was over (no gas was evolved). The reaction mixture was cooled down to room temperature and the cake obtained was dissolved in acetone. Evaporation of the acetone produced a black material which was extracted with 25% solution of ethyl acetate in hexane. Evaporation of the solvents afforded the crude ketone which was further purified on a short path chromatography (silica, a. hexane, b. 5% ethyl acetate in hexane). This afforded 10.1 g (65.4%) of 2,7-dimethylfluorenone.

Provenance & Evidence