Thionyl Chloride → 3-(2-Methoxyfluoren-9-yl)propionyl Chloride

HRID 1089858Notes

Reaction equation

HRID 1089858 reaction equation
[CH3:1][O:2][C:3]1[CH:15]=[CH:14][C:13]2[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[CH:6]([CH2:16][CH2:17][C:18]([OH:20])=O)[C:5]=2[CH:4]=1.O=S(Cl)[Cl:23]>CO.O>[CH3:1][O:2][C:3]1[CH:15]=[CH:14][C:13]2[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[CH:6]([CH2:16][CH2:17][C:18]([Cl:23])=[O:20])[C:5]=2[CH:4]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 199784213-(2-Methoxyfluoren-9-yl)propionic acid

Product 1

HCID 199784093-(2-Methoxyfluoren-9-yl)propionyl Chloride

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

3-(2-Methoxyfluoren-9-yl)propionic acid (1.6 g, 5.2 mmol) was charged with SOCl2 (20 mL, in excess) at room temperature. The reaction mixture was boiled for 2 hr. The reaction was monitored by TLC (silica RP-18, 70% methanol/water). The excess of thionyl chloride was removed under reduced pressure, the residue (an oil) was used for the next step without further purification.

Workup

  1. customThe excess of thionyl chloride was removed under reduced pressure
  2. customthe residue (an oil) was used for the next step without further purification

Sources & evidence

ORD record
ord-96dcf099926c45858f39c04ec0ca70a9
Source dataset
uspto-grants-1992_01
Patent number
US05079260

Reaction notes

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