Thionyl Chloride → HCID 15045079, compound

HRID 1089861Notes

Reaction equation

HRID 1089861 reaction equation
[CH3:1][C:2]1[C:14]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[CH:7]([CH2:15][CH2:16][C:17]([OH:19])=O)[C:6]=2[CH:5]=[CH:4][CH:3]=1.O=S(Cl)[Cl:22]>CO.O>[CH3:1][C:2]1[C:14]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[CH:7]([CH2:15][CH2:16][C:17]([Cl:22])=[O:19])[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 15045078HCID 15045078, compound

Product 1

HCID 15045079HCID 15045079, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

3-(4-Methylfluoren-9-yl)propionic acid (3.5 g, 13 9 mmol) was charged with SOCl2 (20 mL, in excess) at room temperature. The reaction mixture was boiled for 2 hr. The reaction was monitored by TLC (silica RP-18, 70% methanol/water). The excess of thionyl chloride was removed under reduced pressure, the residue (an oil) was used for the next step without further purification.

Workup

  1. customThe excess of thionyl chloride was removed under reduced pressure
  2. customthe residue (an oil) was used for the next step without further purification

Sources & evidence

ORD record
ord-9c8f10c0a87742fbb726342f4032061f
Source dataset
uspto-grants-1992_01
Patent number
US05079260

Reaction notes

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