Toluene → HCID 14476648, compound

Participants

Reaction Steps

2 l of toluene and 155 g (1.84 mole) of sodium bicarbonate are then added to the solution of 2-chloro 3-(1,1-dimethyl 2-chloro-ethyl)aminocarbonylpyridine thus formed and the mixture is refluxed with vigorous stirring until the starting material has completely disappeared (10 to 15 H). The water formed by the reaction of the hydrochloric acid liberated with the sodium bicarbonate is collected in a separator, and the sodium chloride formed is filtered off and washed with toluene. The filtrate is then concentrated under reduced pressure to give 2-chloro 3-(4,4-dimethyl 2-oxazolinyl)pyridine in the form of a yellow oil which can be purified by distillation under reduced pressure.

Provenance & Evidence