N,N-Diethyl-4-formyl-2-methoxynicotinamide → (1-Benzenesulfonyl 5-aza 2-indolyl) (3-diethylaminocarbonyl 2-methoxy 4-pyridyl)methanol

HRID 1089913Notes

Reaction equation

HRID 1089913 reaction equation
[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[CH:14][N:15]=[CH:16][CH:17]=3)[CH:12]=[C:11]2[Li])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:20]([N:22]([CH2:35][CH3:36])[C:23]([C:25]1[C:26]([O:33][CH3:34])=[N:27][CH:28]=[CH:29][C:30]=1[CH:31]=[O:32])=[O:24])[CH3:21].C1(S(N2C3C(=CC(OC)=CC=3)C=C2[Li])(=O)=O)C=CC=CC=1>>[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[CH:14][N:15]=[CH:16][CH:17]=3)[CH:12]=[C:11]2[CH:31]([C:30]2[CH:29]=[CH:28][N:27]=[C:26]([O:33][CH3:34])[C:25]=2[C:23]([N:22]([CH2:20][CH3:21])[CH2:35][CH3:36])=[O:24])[OH:32])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 11806629N,N-Diethyl-4-formyl-2-methoxynicotinamideHCID 178506645HCID 178506645, compoundHCID 178506647HCID 178506647, compound

Product 1

HCID 11016491(1-Benzenesulfonyl 5-aza 2-indolyl) (3-diethylaminocarbonyl 2-methoxy 4-pyridyl)methanol

Procedure

Starting from 1-benzenesulfonyl 2-lithio 5-aza indole and 3-diethylaminocarbonyl 4-formyl 2-methoxy pyridine as reagent with electorphilic character, prepared according to paragraph (b) [stabilization reagent: tris(dioxa-3,6 heptyl)amine; amine: diisopropylamine]. White solid.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-979cd2cb4c00495e9b47567568ce198e
Source dataset
uspto-grants-1992_01
Patent number
US05079363

Reaction notes

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