4-Acetyl 3-diisopropylaminocarbonyl 2-methoxy pyridine → 1-(1-Benzenesulfonyl 5-aza 2-indolyl) 1-(3-diisopropylaminocarbonyl 2-methoxy 4-pyridyl)ethanol

HRID 1089915Notes

Reaction equation

HRID 1089915 reaction equation
[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[CH:14][N:15]=[CH:16][CH:17]=3)[CH:12]=[C:11]2[Li])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:20]([C:23]1[CH:28]=[CH:27][N:26]=[C:25]([O:29][CH3:30])[C:24]=1[C:31]([N:33]([CH:37]([CH3:39])[CH3:38])[CH:34]([CH3:36])[CH3:35])=[O:32])(=[O:22])[CH3:21].C1(S(N2C3C(=CC(OC)=CC=3)C=C2[Li])(=O)=O)C=CC=CC=1>>[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[CH:14][N:15]=[CH:16][CH:17]=3)[CH:12]=[C:11]2[C:20]([C:23]2[CH:28]=[CH:27][N:26]=[C:25]([O:29][CH3:30])[C:24]=2[C:31]([N:33]([CH:37]([CH3:39])[CH3:38])[CH:34]([CH3:36])[CH3:35])=[O:32])([OH:22])[CH3:21])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 144766584-Acetyl 3-diisopropylaminocarbonyl 2-methoxy pyridineHCID 178506645HCID 178506645, compoundHCID 178506647HCID 178506647, compound

Product 1

HCID 679172251-(1-Benzenesulfonyl 5-aza 2-indolyl) 1-(3-diisopropylaminocarbonyl 2-methoxy 4-pyridyl)ethanol

Procedure

Starting from 1-benzenesulfonyl 2-lithio 5-aza indole and 4-acetyl 3-diisopropylaminocarbonyl 2-methoxy pyridine as reagent with electrophilic character, prepared according to paragraph (a) (stabilization reagent: tetramethylethylenediamine).

Workup

  1. customprepared

Sources & evidence

ORD record
ord-e6f7b330297040d9a8247eb15c40c8d5
Source dataset
uspto-grants-1992_01
Patent number
US05079363

Reaction notes

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