2,2,6,6-Tetramethylpiperidine → HCID 178418821, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 0.15 mole of lithium 2,2,6,6-tetramethylpiperidide is prepared by the addition of 0.15 mole of n-butyllithium to 0.15 mole of 2,2,6,6-tetramethylpiperidine in 120 ml of tetrahydrofuran at a temperature lower than -20° C. This solution is then added over a period of a few minutes to 0.1 mole of 1-benzenesulfonyl 5-aza indole cooled to -70° C. while maintaining this temperature throughout the addition. 0.15 mole of anhydrous manganous chloride is then added to the solution of 1-benzenesulfonyl 2-lithio 5-aza indole. The temperature of the medium is then brought from -65° C. to -25° C. in order to bring the exchange reaction to completion and obtain a solution of the desired manganous derivative which is used as such.

Provenance & Evidence