HRID1089922

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cn1nnnc1SCC1=C(C(=O)O)N2C(=O)C(N)[C@H]2SC1

HCID13020813

未命名化合物

结构：CC(C)(C)OC(=O)CON=C(C(=O)O)c1ccc(O)c(Cl)c1

HCID136149112

未命名化合物

PRODUCTS

生成物

结构：Cn1nnnc1SCC1=C(C(=O)O)N2C(=O)C(NC(=O)C(=NOCC(=O)OC(C)(C)C)c3ccc(O)c(Cl)c3)[C@H]2SC1

HCID137195924

未命名化合物

收率 77.3%

PROCEDURE

实验过程

2-t-Butoxycarbonylmethoxyimino-2-(3-chloro-4-hydroxyphenyl)acetic acid (syn isomer) (1 g.) and 7-amino-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid (1 g.) were reacted according to similar manners to those of Examples 1 and 2 to give powder of 7-[2-t-butoxycarbonylmethoxyimino-2-(3-chloro-4-hydroxyphenyl)acetamido]-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid (syn isomer) (1.5 g.).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-61ca7d1de60f45ce97ad62ce123dcfdd
来源数据集: uspto-grants-1992_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05079369
来源说明: uspto-grants-1992_01

反应 SMILES

[C:1]([O:5][C:6]([CH2:8][O:9][N:10]=[C:11]([C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[C:17]([Cl:22])[CH:16]=1)[C:12]([OH:14])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:23][CH:24]1[C:42](=[O:43])[N:26]2[C:27]([C:39]([OH:41])=[O:40])=[C:28]([CH2:31][S:32][C:33]3[N:37]([CH3:38])[N:36]=[N:35][N:34]=3)[CH2:29][S:30][C@H:25]12>>[C:1]([O:5][C:6]([CH2:8][O:9][N:10]=[C:11]([C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[C:17]([Cl:22])[CH:16]=1)[C:12]([NH:23][CH:24]1[C:42](=[O:43])[N:26]2[C:27]([C:39]([OH:41])=[O:40])=[C:28]([CH2:31][S:32][C:33]3[N:37]([CH3:38])[N:36]=[N:35][N:34]=3)[CH2:29][S:30][C@H:25]12)=[O:14])=[O:7])([CH3:2])([CH3:3])[CH3:4]