HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-Ethylisoxazole-5-carboxanilide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Aniline | HCID 6115 | — |
| Reactant | 3-Ethylisoxazole-5-carbonyl chloride | HCID 12905101 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Ethylisoxazole-5-carboxanilide | HCID 15692911 | 87.1% |
Reaction Steps
11.7 g of aniline are added dropwise to 10.0 g of 3-ethylisoxazole-5-carbonyl chloride in 150 ml of dichloromethane, while cooling with ice. The mixture is stirred overnight at room temperature, water and concentrated hydrochloric acid are added and the organic phase is separated off, washed with sodium bicarbonate solution and evaporated down to give 11.8 g of 3-ethylisoxazole-5-carboxanilide as colorless crystals of melting point 122°-124° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05080708 |
| Source dataset | uspto-grants-1992_01 |
| ORD ID | ord-803f5bed721f49bab3dbac2f5d8197d3 |
| Source note | uspto-grants-1992_01 |