Butyl iodide → HCID 53885111, compound

Participants

Reaction Steps

Silver oxide (77.5 g, 0.3 mol) was added to a mixture of ethyl L-(+)-lactate (49.4 g, 0.4 mol) with 1-iodobutane (100 g, 0.5 mol) over 2 hours, followed by allowing the mixture to stand at room temperature for 3 days, adding ether (30 ml) to dilute it, filtering, distilling off ether, washing the residue with 2N-NaOH aqueous solution, drying it over anhydrous magnesium sulfate and distilling it to obtain ethyl (S)-2-butyloxypropionate (30.7 g) (b.p. 64° C./7 mmHg), adding to this product, 5N-NaOH aqueous solution (50 ml), agitating the mixture at room temperature for 5 hours, pouring it in 6N-HCl (75 ml), adding ether, agitating the mixture, washing the resulting organic layer with water and distilling off ether to obtain (S)-2-butyloxypropionic acid (21.4 g).

Provenance & Evidence