HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Adosupine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | HCID 19914288 | HCID 19914288 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Adosupine | HCID 65661 | — |
Reaction Steps
To 2 g 10-acetamido-5,6-dihydro-11H-dibenzo(b,e)azepine-6,11-dione suspended in 20 ml dimethylformamide are added 710 mg sodium methylate in 10 ml methanol. After keeping at ambient temperature for 30 minutes, 2.5 ml methyl iodide are added and the mixture then kept at ambient temperature for 24 hours. It is then poured into water, filtered, dried and crystallized from ethanol: yield 1.6 g, melting point 203°-204° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05080905 |
| Source dataset | uspto-grants-1992_01 |
| ORD ID | ord-2bac8d8c4aa540b0a5e0f61f3bd8e4e7 |
| Source note | uspto-grants-1992_01 |