Potassium Hydroxide → HCID 14577394, compound

HRID 1090099Notes

Reaction equation

HRID 1090099 reaction equation
[OH-].[K+].CC1C=C(C=CC=1)C([O:9][CH2:10][CH:11]1[CH2:16][CH2:15][N:14]([C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([CH3:25])[CH:20]=2)=[O:18])[CH2:13][CH2:12]1)=O>C(O)C.O>[CH3:25][C:21]1[CH:20]=[C:19]([C:17]([N:14]2[CH2:13][CH2:12][CH:11]([CH2:10][OH:9])[CH2:16][CH2:15]2)=[O:18])[CH:24]=[CH:23][CH:22]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 14577393HCID 14577393, compound

Product 1

HCID 14577394HCID 14577394, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolvent2×HCID 962WaterSolvent

Conditions

Temperature
20 °C

Procedure

A solution of 12.76 g (0.23 mol) of potassium hydroxide in 75 ml of ethanol and 75 ml of water is added to a solution of 80 g (0.23 mol) of {1-[(3-methylphenyl)carbonyl]-4-piperidyl}methyl 3-methylbenzoate in 400 ml of ethanol. The mixture is stirred at 20° C. for 3 h, the ethanol is evaporated off under reduced pressure and the aqueous phase is extracted with ethyl acetate. The organic phase is washed with water and then with saturated aqueous sodium chloride solution and dried over magnesium sulphate. The solvent is evaporated off under reduced pressure, and 53 g of alcohol are obtained, this alcohol being used without further treatment in the next stage.

Workup

  1. customthe ethanol is evaporated off under reduced pressure
  2. extractionthe aqueous phase is extracted with ethyl acetate
  3. washThe organic phase is washed with water
  4. dry with materialwith saturated aqueous sodium chloride solution and dried over magnesium sulphate
  5. customThe solvent is evaporated off under reduced pressure, and 53 g of alcohol
  6. customare obtained

Sources & evidence

ORD record
ord-3036219c27ad4323a8ce7582f09feebe
Source dataset
uspto-grants-1992_01
Patent number
US05081128

Reaction notes

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