4-Toluenesulfonyl chloride → HCID 14577395, compound

Participants

Reaction Conditions

Reaction Steps

53.3 g (0.28 mol) of 4-methylphenylsulphonyl chloride in 60 ml of pyridine are added to a solution of 52 g (0.22 mol) of 1-[(3-methylphenyl)carbonyl]-4-piperidinemethanol in 100 ml of pyridine. The mixture is stirred at 20° C. for 4 h and then poured into ice. The phase is extracted with dichloromethane and the organic phase is washed with 10N aqueous hydrochloric acid solution and dried over magnesium sulphate. The solvents are evaporated off under reduced pressure and 70 g of white solid are obtained. Melting point: 68°-70° C.

Provenance & Evidence